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Synchron : Bio Analytical Method

» Following are the Bioanalytical Methods Developed at Synchron Research:

NO. DRUG DETECTOR LLOQ ULOQ UNIT MATRIX USED
 
1 Acyclovir LC-MS/MS 10.433 2025.904 ng/ml Human Plasma
2 Amitriptyline LC-MS/MS 0.990 96.130 ng/ml Human Plasma
Nortriptyline LC-MS/MS 0.984 95.539 ng/ml Human Plasma
3 Amlodipine LC-MS/MS 0.211 36.254 ng/ml Human Plasma
4 Amlodipine LC-MS/MS 0.199 20.089 ng/ml Human Plasma
5 Amoxicillin HPLC UV 0.203 16.215 µg/ml Human Plasma
6 Amoxicillin HPLC Fluorescence 0.200 15.984 µg/ml Human Plasma
7 Amoxicillin LCMS/MS 0.104 16.755 µg/ml Human Plasma
8 Anagrelide LC-MS/MS 0.498 32.226 ng/ml Human plasma
9 Apovincaminic acid LC-MS/MS 1.144 305.100 µg/ml Human Plasma
10 Atorvastatin LC-MS/MS 0.199 1990.558 ng/ml Human Plasma
Orthohydroxy Atorvastatin LC-MS/MS 0.237 47.394 ng/ml Human Plasma
Parahydroxyatorvastatin LC-MS/MS 0.249 49.910 ng/ml Human Plasma
11 * Azacitidine LCMS/MS       Rabbit Plasma+Partially validated
12 Azelaic Acid LC-MS/MS 535.135 54166.667 ng/ml Per Sq. cm Adhesive disk
13 Azithromycin HPLC ECD 24.350 1175.959 ng/ml Human Plasma
14 Azithromycin LC-MS/MS 4.760 610.578 ng/ml Human Plasma
15 Bendroflumethiazide HPLC Fluorescence 0.986 100.160 ng/ml Human Plasma
16 Bupreonorphine LC-MS 55.826 7458.987 pg/ml Human Plasma
17 Cefpodoxime HPLC UV 0.475 27.967 µg/ml Human Plasma
18 Cefprozil HPLC UV 0.478 28.144 µg/ml Human Plasma
19 Cefuroxime Sodium HPLC UV 0.226 26.636 µg/ml Human Plasma
20 Cephalexin HPLC UV 0.111 39.992 µg/ml Human Plasma
21 Cetrizine HPLC UV 26.477 1314.742 ng/ml Human Plasma
22 Cetrizine LC-MS/MS 2.752 1054.239 ng/ml Human Plasma
23 Ciprofloxacin HPLC UV 0.054 7.992 µg/ml Human Plasma
24 Clarithromycin HPLC ECD 24.293 2000.000 ng/ml Human Plasma
25 Clavulanic Acid HPLC UV 0.031 8.952 µg/ml Human Plasma
26 Clobazam HPLC UV 9.937 806.400 ng/ml Human Plasma
27 Clobazam LC-MS/MS 0.010 0.839 µg/ml Human Plasma
28 Cyclosporine LC-MS/MS 4.988 503.995 ng/ml Human Blood
29 D3-N,N Di Desmethyl  Venlafaxine LC-MS/MS 2.016 200.738 ng/ml Human Plasma
D3-N,N Di Desmethyl  Venlafaxine LC-MS/MS 2.006 499.437 ng/ml Human Urine
D3-N,O Di Desmethyl  Venlafaxine LC-MS/MS 2.010 200.184 ng/ml Human Plasma
D3-N,O Di Desmethyl  Venlafaxine LC-MS/MS 2.007 499.665 ng/ml Human Urine
D6-N Desmethyl  Venlafaxine LC-MS/MS 2.025 201.678 ng/ml Human Plasma
D6-N Desmethyl  Venlafaxine LC-MS/MS 2.006 499.393 ng/ml Human Urine
D6-O Desmethyl  Venlafaxine LC-MS/MS 2.005 199.676 ng/ml Human Plasma
D6-O Desmethyl  Venlafaxine LC-MS/MS 2.008 499.990 ng/ml Human Urine
D9- Venlafaxine LC-MS/MS 2.007 199.907 ng/ml Human Plasma
D9- Venlafaxine LC-MS/MS 2.008 499.846 ng/ml Human Urine
30 Venlafaxine HPLC Fluorescence 6.159 398.629 ng/ml Human Plasma
Desmethyl Venlafaxine HPLC Fluorescence 10.346 502.236 ng/ml Human Plasma
31 Venlafaxine LC-MS/MS 10.637 2065.425 ng/ml Human Plasma
Desmethyl Venlafaxine LC-MS/MS 10.340 2007.808 ng/ml Human Plasma
32 Dextromethorphan HPLC Fluorescence 9.676 631.818 ng/ml Human Plasma
33 Dextromethorphan LC-MS/MS 0.540 60.455 ng/ml Human Plasma
34 Diltiazem HCL LC-MS/MS 0.479 639.886 ng/ml Human Plasma
Desacetyl Diltiazem LC-MS/MS 0.240 320.703 ng/ml Human Plasma
N-Desmethyl Diltiazem LC-MS/MS 0.240 320.129 ng/ml Human Plasma
35 Diphenhydramine LC-MS/MS 1.545 110.045 ng/ml Human Plasma
36 Diphenhydramine HCl HPLC Fluorescence 15.109 1076.254 ng/ml Human Plasma
37 Docetaxel LCMS/MS 3.871 1000.006 ng/ml Human Plasma
38 Doxycycline HPLC UV 0.100 2.000 µg/ml Human Plasma
39 Estradiol & Estrone LC-MS/MS 15.967 1280.000 pg/ml Bovine serum Albumin
40 Estrdiol & Estrone GCMS 40.030 2588.160 pg/ml Bovine Serum Albumin
41 Ethambutol LCMS/MS 0.122 12.188 µg/ml Human Plasma
42 Ethosuximide LCMS/MS 0.248 60.001 µg/ml Human Plasma
43 Exemestane LC-MS/MS 705.565 51642.081 pg/ml Human Plasma
44 Fenofibric Acid HPLC UV 0.277 20.138 µg/ml Human Plasma
45 Fenofibric Acid LC-MS/MS 0.050 7.129 µg/ml Human Plasma
46 Fexofenadine LC-MS/MS 9.665 500.577 ng/ml Human Plasma
47 Flucloxacillin HPLC UV 0.344 2245.205 µg/ml Human Plasma
48 Fluconazole LC-MS/MS 50.334 5764.428 ng/ml Human Plasma
49 Fluindione HPLC UV 19.951 999.951 ng/ml Human Plasma
50 Fluvastatin LC-MS/MS 2.035 15019.681 ng/ml Human Plasma
51 Fulvestrant LC-MS/MS 0.085 16.040 ng/ml Human Plasma
52 Gabapentin LC-MS/MS 50.637 4823.971 ng/ml Human Plasma
53 Gabapentin LC-MS/MS 9.990 999.000 µg/ml Human Urine
54 Gatifloxacin HPLC UV 0.118 16.002 µg/ml Human Plasma
55 Gliclazide HPLC UV 0.205 11.784 µg/ml Human Plasma
56 Glucosamine LC-MS/MS 49.787 2786.000 ng/ml Human Plasma
57 Granisetron HPLC Fluorescence 0.361 96.378 ng/ml Human Plasma
58 Hydrochlorothiazide LC-MS/MS 5.184 503.284 ng/ml Human Plasma
59 Hydroxyzine LCMS/MS 2.130 198.673 ng/ml Human Plasma
60 Ibuprofen LCMS/MS 0.374 74.897 µg/ml Human Plasma
61 Indomethacin LC-MS/MS 20.016 2001.940 ng/ml Human Plasma
62 Isoniazide HPLC UV 0.272 20.000 µg/ml Human Plasma
63 Isotretinoin HPLC UV 11.040 812.000 ng/ml Human Plasma
64 Itraconazole HPLC Fluorescence 2.094 119.711 ng/ml Human Plasma
65 Lansoprazole LC-MS/MS 5.356 2142.894 ng/ml Human Plasma
66 Meloxicam HPLC UV 51.303 4019.800 ng/ml Human Plasma
67 Metformin HPLC UV 30.000 5000.000 ng/ml Human Plasma
68 Metoprolol HPLC Fluorescence 5.000 500.000 ng/ml Human Plasma
69 Metoprolol LC-MS/MS 0.505 150.761 ng/ml Human Plasma
70 Mizolastine HPLC UV 21.746 1599.414 ng/ml Human Plasma
71 Mosapride HPLC Fluorescence 5.000 100.000 ng/ml Human Plasma
72 Nebivolol LC-MS/MS 0.075 8.000 ng/ml Human Plasma
73 Nicotine LC-MS/MS 1.001 101.773 ng/ml Human Plasma
Cotinine LC-MS/MS 1.008 102.433 ng/ml Human Plasma
74 Nifedipine LC-MS/MS 0.500 200.376 ng/ml Human Plasma
75 Norethisterone LC-MS/MS 279.976 16032.000 pg/ml Human Plasma
76 Norfloxacin HPLC Fluorescence 4.990 800.097 ng/ml Human Plasma
77 Olanzapine LC-MS/MS 0.510 100.148 ng/ml Human Plasma
78 Oxcarbazepine LC-MS/MS 10.250 5070.362 ng/ml Human Plasma
10-OH,10,11 Dihydro Carbamazepine LC-MS/MS 102.181 10109.049 ng/ml Human Plasma
10-OH,10,11 Dihydro Carbazepine LC-MS/MS 212.624 9902.819 ng/ml Human Plasma
79 Oxybutynin LC-MS/MS 75.050 7078.222 pg/ml Human Plasma
N- Desethyl Oxybutynin LC-MS/MS 75.258 7097.896 pg/ml Human Plasma
80 Paracetamol LC-MS/MS 154.099 10062.000 ng/ml Human Plasma
81 Paroxetine LC-MS/MS 0.317 30.783 ng/ml Human Plasma
82 Paroxetine LC-MS/MS 0.050 16.710 ng/ml Human Plasma
83 Penciclovir LC-MS/MS 52.555 6626.181 ng/ml Human Plasma
84 Piperacillin HPLC UV 1.005 100.049 µg/ml Human Plasma
85 Pramipexole LC-MS/MS 0.100 15.426 ng/ml Human Plasma
86 Prochloroperazine LCMS/MS 15.378 1401.351 pg/ml Human Plasma
87 Progesterone LC-MS/MS 0.418 113.344 ng/ml Human Plasma
88 Progesterone LC-MS/MS 0.101 27.227 ng/ml Human Serum
89 Propranolol HPLC Fluorescence 4.915 641.812 ng/ml Human Plasma
90 Pyrazinamide HPLC UV 0.400 40.004 µg/ml Human Plasma
91 Quetiapine LC-MS/MS 10.075 2008.936 ng/ml Human Plasma
92 Quinaprilat LC-MS/MS 25.288 2455.200 ng/ml Human Plasma
Quinpril LC-MS/MS 4.541 454.214 ng/ml Human Plasma
93 Ranitidine HPLC UV 0.025 1.801 µg/ml Human Plasma
94 Reboxetine HPLC UV 20 to  500.000 ng/ml Human Plasma
95 Resveratrol LC-MS/MS 5.761 2405.484 ng/ml Human Plasma
96 Retinoic acid HPLC UV 21.655 2424.000 ng/ml Human Plasma
97 Roxithromycin HPLC UV 0.500 200.000 µg/ml Human Plasma
98 Roxithromycin HPLC ECD 0.427 20.116 µg/ml Human Plasma
99 Sertraline HPLC UV 0.011 0.432 µg/ml Human Plasma
100 Sildenafil HPLC UV 6.603 480.337 ng/ml Human Plasma
101 Sumatriptan LCMS/MS 1.028 97.912 ng/ml Human Plasma
102 Terbinafine LC-MS/MS 15.917 1595.527 ng/ml Human Plasma
103 Tianeptine LC-MS/MS 2.517 500.941 ng/ml Human Plasma
104 Topiramate LC-MS/MS 0.025 5.050 µg/ml Human Plasma
105 Torsemide LC-MS/MS 0.063 24.002 µg/ml Human Plasma
106 Torsemide LC-MS/MS 0.126 24.007 µg/ml Human Urine
107 Trifluoperazine GCMS 4.845 316.361 ng/ml Human Plasma
108 Trimetazidine LC-MS/MS 1.195 119.519 ng/ml Human Plasma
109 Ursodiol LC-MS/MS 30.400 3040.000 ng/ml Human Plasma
Glycodeoxycholic Acid (GDCA) LC-MS/MS 30.415 3041.529 ng/ml Human Plasma
Sodium Tauroursodeoxycholate (TDCA) LC-MS/MS 30.396 3039.597 ng/ml Human Plasma
110 Valproic Acid LC-MS/MS 0.560 100.980 µg/ml Human Plasma
111 Vinpocetine LC-MS/MS 0.193 25.754 ng/ml Human Plasma
112 Warfarin HPLC Fluorescence 11.087 1115.814 ng/ml Human Plasma
113 Ziprasidone LC-MS/MS 0.669 199.999 ng/ml Human Plasma
114 Zolpidem HPLC Fluorescence 5.923 441.196 ng/ml Human Plasma
115 Zopiclone HPLC UV 1.052 102.169 ng/ml Human Plasma
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